The Cleanse - Spermidine+

The Cleanse is a natural supplement that supports your body’s natural processes for cellular renewal and repair. It mimics the benefits of fasting by promoting autophagy, a self-cleaning process where your cells remove waste and renew themselves. It also helps reduce inflammation and clears out senescent cells—ageing cells that can contribute to damage—leaving your body rejuvenated and running more efficiently. Ingredients like Spermidine clean out cellular "muck," while Quercetin and Curcumin reduce cellular wear and tear, helping you feel revitalised and promoting healthier ageing.

We recommend taking 1-2 capsules per day with all three ingredients being safe and tolerated well within these levels. We often suggest starting with 1 capsule per day to allow your body time to adjust and based on how you feel, increase as you go. Additionally, if you are taking The Cleanse specifically for joint pain or better physical performance, the higher dose of 2 capsules per day is generally advised.

For 2 years, quercetin has been a cornerstone of cellular health products, and it’s earned its reputation as a powerful antioxidant and senolytic (eliminates senescent or “zombie cells”).

But as science progresses, so do we.

When creating The Cleanse, we revisited our formulation to ensure it offered the most effective, targeted support for cellular renewal and autophagy. This meant balancing the ingredients to deliver maximum results in the most efficient way possible.

Here’s why The Cleanse now features 250mg of Quercefit® Phytosome, instead of 500mg:

• More doesn’t always mean better. Thanks to its patented technology, even at the 250mg level of Quercefit® Phytosome™, there are huge health benefits. It’s actually ≈10x more bioavailable compared to 500mg of regular quercetin—meaning it’s still an ideal, science-backed dose.
• Room for innovation. By optimising the quercetin dosage, we created space for other incredible ingredients like Spermidine and Curcumin Phytosome, amplifying The Cleanse’s ability to clear out damaged cells, reduce inflammation, and activate autophagy.

What does this mean for you?

You can tailor our products to your needs > If your focus is cellular cleansing and renewal, The Cleanse is your go-to. But if sports performance and recovery are your priority, our original product, The Zombie, remains the best choice with its 500mg of Quercefit®.

Your health deserves nothing but the most effective solutions, and The Cleanse reflects our commitment to delivering just that.

Yes, all three ingredients — Spermidine, Curcumin and Quercetin are generally considered safe for human consumption. No significant side effects have been documented in human trials. However, some participants have reported mild gastrointestinal symptoms, such as nausea, gas, changes in bowel movements, and diarrhoea. If you have any concerns, discontinue use and consult a healthcare provider. Additionally, if you have hypothyroidism or are on thyroid medication, you should not take this product prior to consulting your physician.

For the best results, take The Cleanse on an empty stomach.

The timing can also depend on your personal goals:

If you prefer morning: Taking The Cleanse with your first meal can extend the benefits of overnight fasting and support cellular renewal throughout the day.

If you prefer evening: Taking it with your last meal can help activate autophagy (cellular renewal) and support repair processes while you sleep.

Ultimately, the best time is the one that fits your routine and ensures consistency.

38% increase in NAD+ within 60 days, based on Huang H. A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults. Front ageing. May 2022.

Retain up to 50% more NAD+ over time, based on Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. April 2013.

Contains 80% more NMN than The Base, based on nutritional information panel.

Reduces joint pain and improves mobility by lowering harmful inflammation markers, based on Randomized Controlled Trial of Oral Glutathione Supplementation on Body Stores of Glutathione, 2015.

Mimics calorie restriction for autophagy, based on Spermidine: A Novel Autophagy Inducer and Longevity, 2010.

Clears senescent cells, based on Senolytic Drugs, Dasatinib and Quercetin, Attenuate Adipose Tissue Inflammation and Ameliorate Metabolic Function in Old Age, June 2022.

Up to 29x more absorption compared to non-phytosome ingredients, based on Improved Oral Absorption of Quercetin from Quercetin Phytosome®, a New Delivery System Based on Food Grade Lecithin, April 2019.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Supplements should not replace a balanced diet. These products are not intended to diagnose, treat, cure or prevent any disease. Always read the label before ingestion. When in doubt, always seek the advice of a health or medical professional.