The Neuro Defence System combines The Brain for AM clarity and cognitive performance with The Unwind for PM calm and overnight brain restoration — supporting focus by day, recovery by night, and long-term brain protection.
Stay sharp by day. Restore by night. The Neuro Defence System is a complete day-and-night brain support system designed to sharpen focus, build stress resilience, and support deep, restorative sleep — protecting cognitive health now and long term.
By pairing an advanced nootropic formula with a clinically studied brain calm and sleep complex, it supports daily performance while enhancing overnight brain repair and recovery.
Daily benefits:
Sharper focus, clarity, and memory
Improved stress resilience and mood balance
Reduced mental fatigue
Deeper, more restorative sleep
Overnight brain recovery
Healthier brain ageing
How it works:
By day, Rhodiola rosea supports stress resilience and sustained performance, Ginkgo biloba 24/6 enhances cerebral blood flow for focus and memory, and ErgoX™ Ergothioneine helps protect neurons from oxidative stress.
By night, Magtein® magnesium L-threonate — the only magnesium proven to cross the blood–brain barrier — supports sleep regulation, while L-theanine promotes calm, relaxed brain activity for deeper sleep.
We are advised on the science behind our products by our Scientific Board, consisting of leading longevity scientists Prof. Jan Gruber and Prof. Vincenzo Sorrentino.
What's in the bundle
Serving Size:
Day: 1 capsule (The Brain)
Night: 2 capsules (The Unwind)
Origin: Made in France (The Brain) and the US (The Unwind)
Standardisation & Purity: Ginkgo 24/6 is the gold-standard extract used in most clinical trials. ErgoX™ Ergothioneine is ≥99.5% pure and produced to cGMP/ISO standards. Magtein® is clinically studied for brain magnesium delivery.
How to use
The Brain: Take 1 capsule daily, with food, in the morning. Avoid taking in the evening.
The Unwind: Take 2 to 4 capsules in the late afternoon or evening.
Together, they bookend your day — The Brain supports focus when you need it, The Unwind supports recovery when you don't.
Expiry dates & Lab test reports
Triple-tested by independent labs. Unlike most brands.
We screen every batch for purity, safety, and potency — so you know exactly what’s in every capsule.
We typically ship the latest batches, each with an expiry date at least 1–2 years ahead, ensuring lasting freshness and stability.
The only magnesium proven to cross the blood–brain barrier⁽¹⁾
2×
Improved deep sleep scores vs placebo in 2 weeks⁽²⁾
4.8×
Greater mood improvement vs placebo in 3 weeks⁽²⁾
2.5×
Memory improvement at 4 weeks⁽³⁾
We are advised on the science behind our products by our Scientific Board, consisting of leading longevity scientists Prof. Jan Gruber and Prof. Vincenzo Sorrentino. ⁽¹⁾ Slutsky I. et al., 2010, Neuron ⁽²⁾ Hausenblas H.A. et al., 2024, Sleep Medicine ⁽³⁾ Zajac I.T. et al., 2025, Nutraceuticals
Trusted by 10,000s of customers.
A COMPLETE DAILY SYSTEM
What’s Included
Brain ageing is cumulative stress. The Neuro Defence System defends by day and repairs by night to combat cognitive decline over time whilst unlocking short-term focus and deep sleep.
If you're not satisfied, just tell us about your experience.
Deep Sleep, Restored Mind
Sleep deeper, wake sharper, feel calm.
Clarity Today, Sharper Tomorrow.
Support memory, protect neurons, and strengthen cognitive resilience — today’s clarity layered with tomorrow’s brain protection.
Why Choose The Neuro Defence System?
Others
Day + night brain support system
Clinically studied, patented ingredients
Gold-standard Ginkgo 24/6 & Magtein® magnesium
Lab test certificates published online
Made in France and the US under GMP
High Standards. No Compromises.
Every ingredient is tested, verified, and obsessively sourced—because good enough isn’t good enough.
Ingredients in The Unwind
Magtein® Magnesium L-Threonate, L-Theanine
Ingredients in The Unwind
Magtein® magnesium L-threonate uniquely crosses the blood–brain barrier to support sleep, relaxation, and brain health. Paired with L-theanine, a tea-derived amino acid that boosts calming alpha brain waves, it reduces stress and promotes relaxed focus — without drowsiness or energy crashes.
ErgoX™ Ergothioneine is a pure antioxidant amino acid that accumulates in the brain to support long-term cognitive protection. Combined with gold-standard Ginkgo biloba 24/6 for blood flow and clarity, and Rhodiola rosea for stress resilience, it supports sharper focus and sustained mental performance.
Meet Our Scientific Advisors.
Jan Gruber
PhD
University of Oxford, UK
Dr. Jan Gruber, PhD, completed his PhD in Biochemistry at the University of Oxford after studying physics and mathematics at the University of Cambridge. He is a biochemist and Associate Professor at the National University of Singapore (NUS), specialising in ageing biology, mitochondrial function, and oxidative stress. His research explores the molecular mechanisms of longevity and has been published in leading journals. His work often uses simple organisms such as tiny worms (C. elegans) to understand how ageing happens at the cellular level and test new ways to slow it down.
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Vincenzo Sorrentino
PhD
University of Amsterdam, NL
Dr. Vincenzo Sorrentino, PhD, completed his PhD in Medical Biochemistry at the University of Amsterdam before going on to study how metabolism and nutrition affect ageing. He is a molecular biologist and Assistant Professor at the National University of Singapore (NUS), specialising in ageing, mitochondrial health, and NAD⁺ metabolism. His research has been published in leading journals including Nature and Cell Reports. His current work looks at how molecules like NAD⁺, which fuel our cells, and the maintenance of proteins in the body, can support healthier ageing.
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Ask Anything.
What is The Neuro Defence System?
The Neuro Defence System is a complete day-and-night brain support system combining The Brain (daytime focus and resilience) and The Unwind (night-time calm and sleep support). Together, they support cognitive performance, stress resilience, sleep quality, and long-term brain health.
How should I take The Neuro Defence System?
Day: Take 1 capsule of The Brain in the morning or early afternoon.
Night: Take 2–4 capsules of The Unwind in the late afternoon or evening, ideally about one hour before bed.
How quickly will I notice results?
Many people notice improved focus, calmer mood, or better sleep within 1–2 weeks, if not days. Deeper benefits — such as steadier energy, improved resilience, and long-term cognitive support — build with consistent daily use over 4–6 weeks.
Is The Neuro Defence System safe?
All ingredients are well-researched, clinically studied, and triple-tested for purity.
However:
Do not use if pregnant or breastfeeding.
Consult your healthcare provider before use if you have a medical condition or take medications — especially antidepressants, blood thinners, sedatives, or blood pressure medication.
Ginkgo biloba may increase bleeding risk in some individuals.
Discontinue use if adverse effects occur.
Who is The Neuro Defence System for?
Adults who want:
Sharper focus and mental clarity
Better stress resilience
Deeper, more restorative sleep
Long-term brain protection as they age
Especially valuable for those under high cognitive or emotional demand.
If you aren’t already familiar with Dr David Sinclair, you should be. A professor at Harvard University, he has been studying ageing for the better part of his academic career...
If you aren’t already familiar with Dr David Sinclair, you should be. A professor at Harvard University, he has been studying ageing for the better part of his academic career...
If you aren’t already familiar with Dr David Sinclair, you should be. A professor at Harvard University, he has been studying ageing for the better part of his academic career...
If you aren’t already familiar with Dr David Sinclair, you should be. A professor at Harvard University, he has been studying ageing for the better part of his academic career...