From discoveries in ageing research to therapeutics for healthy ageing, Campisi J. et al., 2019, Buck Institute for Research on Ageing, USA
For decades, biologists have been unraveling the mysteries of ageing. This article covers key milestones, explores various ageing pathways, and suggests that ageing research is entering a new era with significant impacts.
12 Hallmarks of Ageing, Stella Elyse Lim, 2024. St. Joseph’s Institution International, Singapore
This review explores how key enzymes in ageing, influence the twelve hallmarks of ageing. It highlights their potential as targets for extending healthspan and lifespan, summarising interventions that address age-related changes at multiple levels.
Mitochondrial function and mitochondrial DNA maintenance with advancing age, Gaziev, A.I., et al., 2014
Aging is associated with decreased mitochondrial turnover, leading to an accumulation of dysfunctional mitochondria and mutated mtDNA, primarily due to reduced autophagy and mitophagy.