Glutathione Dosage Guide: How Much Is Safe and Effective?

Glutathione, often called the “master antioxidant,” plays a vital role in detoxification, immune support, and cellular health. But with so many forms and dosages available, figuring out the right amount can feel overwhelming. Let’s break down the science-backed recommendations to help you make informed choices.

When selecting the optimal glutathione supplement, it's essential to consider factors like absorption rates and delivery methods. Options range from liposomal glutathione, known for its enhanced bioavailability, to sublingual formulations that offer rapid absorption. 

For those seeking targeted benefits, glutathione for skin lightening and glutathione for liver support are popular choices. Additionally, understanding the side effects of glutathione and the differences between glutathione and NAC can guide informed decisions. 

Explore our comprehensive glutathione supplements collection to find the right fit for your health goals.

Your body produces glutathione naturally, but factors like aging, stress, and environmental toxins can deplete it. Low levels are linked to fatigue, weakened immunity, and accelerated aging. Supplementing with glutathione can help restore balance, but dosage matters—too little might not work, and too much could cause side effects.

Most studies use 250–1,000 mg daily for general health. For example:

• 250 mg/day improved skin clarity and reduced oxidative stress in healthy adults.

• 500–1,000 mg/day boosted glutathione levels in people with liver conditions or chronic inflammation.

However, oral glutathione has lower absorption rates. Liposomal or sublingual forms may be more effective at lower doses.

IV delivery bypasses digestion, making it ideal for therapeutic use:

• 600–1,200 mg/week for general wellness.

• 1,200–2,400 mg/week for skin brightening or chronic conditions.

• 2% glutathione creams applied daily improved skin tone in clinical trials.

• 600 mg nebulized twice daily helped lung function in cystic fibrosis patients.

Glutathione is generally safe, but exceeding 2,000 mg/day orally or 3,000 mg/week via IV may cause:

• Nausea or stomach cramps.

• Skin rashes (rare).

• Bronchial irritation if inhaled.

• Pregnant or breastfeeding women (limited data).

• People with asthma (inhaled forms).

• Those on chemotherapy (consult a doctor first).

Not all glutathione products are equal. Look for:

1. Third-party testing (e.g., NSF or USP certification).

2. Bioavailable forms like liposomal or S-acetyl glutathione.

3. Combination formulas with vitamin C or selenium for better absorption.

Pro tip: Start with a low dose (e.g., 100–250 mg) and increase gradually over 2–4 weeks.

The Protect – Glutathione+

Cellular Shield. Skin Radiance. Immune Strength.

Experience a new era of protection with The Protect, powered by Setria® Glutathione and Sulfodyne® Sulforaphane — the most bioavailable forms of nature’s two most powerful detox and defense compounds. Crafted with patented absorption technology and backed by science, this formula goes deep to protect your cells at the DNA level.

Why You'll Love It:

- Glowing, youthful skin – visibly improves elasticity and reduces fine lines
- Less daily stress – reduces oxidative damage by up to 38%
- Stronger immunity – doubles your body’s natural defense mechanisms
- Cleaner, healthier body – supports liver, kidney, and full-body detox
- Feel more energized – restores cellular vitality and improves recovery

How It Works:

Think of your body like a garden:

-Glutathione clears out free radicals—like weeds—so your cells can thrive.
- Sulforaphane nourishes the soil—deeply enriching your system at the root level.

Together, they rebuild a stronger, more resilient you from the inside out.

Science-Backed Ingredients:

• Setria® Glutathione (250mg) – Fermented for unmatched purity & absorption

• Sulfodyne® Sulforaphane (100mg) – From broccoli seed extract, stabilized for 7x better uptake

Made in France | Each batch independently tested for purity

How to Take:

Take 1 capsule daily (up to 2 if needed), ideally on an empty stomach.

Each bottle = 30-day supply