The Best Supplements for Longevity? Start With How Ageing Actually Works
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Time to read 3 min
Most people think of ageing as grey hairs and joint pain.
But real ageing starts much earlier — deep inside your cells .
At For Youth, we don’t see ageing as some mysterious force.
We see it as what it is:
Ageing is cell damage.
And if damage is the problem, then longevity isn’t about magic pills or miracle cures.
It’s about helping your cells repair , protect , and cleanse themselves — every day.
That’s what the Age Defence System is built for.
A science-backed longevity protocol created in collaboration with Professors Jan Gruber and Vincenzo Sorrentino at NUS — both world-class researchers in the biology of ageing.
Why Most Anti-Ageing Supplements Don’t Cut It
Search for “best supplements for longevity” and you’ll find everything from NMN to collagen to exotic herbs.
But most of these products treat symptoms — not causes.
True longevity begins by addressing the 12 Hallmarks of Ageing — the biological drivers behind why we age.
To slow down ageing , you need to address these at the source.
The 12 Hallmarks of Ageing — and What to Do About Them
Scientists have mapped out 12 distinct processes that lead to biological decline. They include things like DNA damage, faulty mitochondria, chronic inflammation, and accumulation of senescent cells. Each one chips away at your vitality over time.
Here they are:
Genomic Instability – DNA damage
Telomere Attrition – Shortening of chromosome caps
Epigenetic Alterations – Gene expression errors
Loss of Proteostasis – Faulty or misfolded proteins
Disabled Macroautophagy – Blocked cellular cleanup
Deregulated Nutrient Sensing – Broken metabolic signals
Mitochondrial Dysfunction – Declining energy production
Cellular Senescence – Zombie cells
Stem Cell Exhaustion – Reduced repair capacity
Altered Intercellular Communication – Mixed signals between cells
Chronic Inflammation – Ongoing immune stress
Dysbiosis – Gut microbiome imbalance
Enter: The Age Defence System
Not just one supplement — but three. Each targets different hallmarks of ageing.
Individually powerful. Together, they form a daily protocol to keep your cells younger for longer.
🧬 The Repair – NMN + Apigenin + L-Tryptophan
“Fuel your NAD+, fix your DNA, reset your rhythm.”
NMN is a direct NAD+ precursor, essential for DNA repair, energy, and mitochondrial health
Apigenin helps block CD38, which depletes NAD+
L-Tryptophan supports serotonin and circadian rhythm
Targets: Genomic instability , epigenetic alterations , mitochondrial dysfunction , stem cell exhaustion , telomere attrition , nutrient sensing
🛡 The Protect – Glutathione + Sulforaphane
“Strengthen your defences. Every cell, every day.”
Glutathione is the body’s master antioxidant
Sulforaphane (from broccoli extract) activates the Nrf2 pathway for cellular protection and detox
Targets: Chronic inflammation , loss of proteostasis , oxidative stress , intercellular communication
🧼 The Cleanse – Spermidine + Curcumin (phytosome) + Quercetin (phytosome)
“Clear the waste. Clean the slate.”
Spermidine activates autophagy — the body's own cellular recycling
Curcumin and Quercetin (phytosome forms) clear senescent cells and reduce inflammatory burden
Targets: Autophagy , cellular senescence , dysbiosis , inflammation , loss of proteostasis
How It All Maps to the Hallmarks of Ageing
| Hallmark of Ageing | The Repair | The Protect | The Cleanse |
|---|---|---|---|
| Genomic Instability | ✅ | ||
| Telomere Attrition | ✅ | ||
| Epigenetic Alterations | ✅ | ||
| Loss of Proteostasis | ✅ | ✅ | |
| Disabled Macroautophagy | ✅ | ||
| Deregulated Nutrient Sensing | ✅ | ||
| Mitochondrial Dysfunction | ✅ | ||
| Cellular Senescence | ✅ | ||
| Stem Cell Exhaustion | ✅ | ||
| Altered Intercellular Communication | ✅ | ||
| Chronic Inflammation | ✅ | ✅ | |
| Dysbiosis | ✅ |
Built by Scientists, Not Marketers
The Age Defence System was developed with two scientists who don’t just study ageing — they build tools to slow it down:
Jan Gruber – A biogerontologist whose lab focuses on how molecular repair mechanisms can extend lifespan.
Vincenzo Sorrentino – A cellular ageing expert focused on mitochondria, NAD+ metabolism, and how hallmarks of ageing interact.
They brought their research into the real world — so you can bring longevity into your daily life.
How to Live Longer (and Better)
You don’t need miracle promises or 30-pill stacks.
You need a strategy.
One that helps your body repair, protect, and cleanse — so you can do more, for longer.
That’s what the Age Defence System is for.
Backed by science. Built for life.
→ Explore the full protocol: The Age Defence System
