Which supplements does Longevity Expert Dr David Sinclair take?

Dr. David Sinclair — the renowned Harvard professor of genetics and bestselling author of Lifespan — is one of the most influential figures in the field of ageing research. A pioneer in the science of epigenetics and cellular longevity, his work has helped shift the global conversation around what it means to grow older. Instead of treating ageing as an inevitable decline, Sinclair positions it as a condition we may one day be able to slow, halt, or even reverse.

His personal supplement routine has become something of a blueprint for biohackers, longevity enthusiasts, and scientists alike. Drawing from his decades of research, Sinclair’s stack is designed to target the hallmarks of ageing — especially mitochondrial decline and epigenetic dysregulation — with a focus on boosting cellular repair and resilience.

At the core of his regimen is NMN (nicotinamide mononucleotide) , a compound that helps increase NAD+ , a coenzyme essential for energy production, DNA repair, and cellular metabolism. As we age, NAD+ levels drop dramatically, contributing to fatigue, inflammation, and metabolic dysfunction. Sinclair’s lab and others have shown that restoring NAD+ in older mice using NMN can improve mitochondrial function, enhance endurance, and even restore aspects of youthful gene expression.

Another cornerstone of his routine is resveratrol , a polyphenol found in red wine and grapes. Resveratrol activates sirtuins , a family of proteins that help regulate cellular health and repair under stress. While early research faced bioavailability challenges, later studies — including Sinclair’s own — demonstrated that when combined with fat (such as yoghurt), resveratrol could mimic some of the effects of calorie restriction, including improved insulin sensitivity, reduced inflammation, and extended lifespan in animal models.

Together, NMN and resveratrol form the foundation of Sinclair’s longevity approach — targeting both energy metabolism and the epigenetic switches that determine how our cells age. His broader stack also includes other compounds such as quercetin, spermidine, and metformin (under doctor supervision), all aimed at enhancing autophagy, reducing senescent cell burden, and optimising metabolic pathways.

If you’ve ever found yourself asking, “What supplements does David Sinclair actually take?” — this guide offers a detailed breakdown of the ingredients he’s publicly discussed, what the science says about them, and how you can begin to build your own evidence-led stack inspired by one of the leading voices in the fight against ageing.

Sinclair has called NMN the cornerstone of his routine. As a precursor to NAD+, NMN plays a critical role in supporting DNA repair, mitochondrial function, and overall energy metabolism. Sinclair takes NMN every morning — and it’s the supplement that put longevity on the mainstream map.

Try The Repair for high-purity NMN, or The Base for a streamlined daily dose:

Resveratrol is best known as the “red wine molecule,” but Sinclair uses it not for the wine — but for its potential to activate sirtuins. These proteins are thought to influence ageing by improving cellular stress resistance and metabolism. He’s often said he takes resveratrol alongside NMN and yoghurt.

Try The Grape — For Youth’s resveratrol formulated for optimal absorption:

Quercetin is a plant flavonoid known for its antioxidant effects and potential senolytic activity — meaning it may help the body clear out ageing cells. Sinclair has discussed its potential benefits, particularly in combination with compounds like fisetin or pterostilbene.

The Zombie offers bioavailable quercetin designed for long-term cellular defence:

This molecule has gained traction for its role in autophagy — the body’s natural cellular clean-up mechanism. Sinclair has spoken positively about its potential in supporting long-term cellular health, particularly in the context of caloric restriction mimetics.

The Cleanse supports autophagy with high quality spermidine, supported by quercetin and curcumin:

While not at the top of Sinclair’s core list, glutathione is one of the most important antioxidants produced by the body. It plays a key role in detoxification and mitochondrial support — two themes that overlap with Sinclair’s broader approach to ageing.

The Protect delivers reduced glutathione to help shield your cells from oxidative stress:

David Sinclair has also mentioned other compounds in interviews and podcast appearances:
– Fisetin (a senolytic plant polyphenol, similar to quercetin)
– TMG (to support methylation alongside NMN, but lacks scientific evidence)
– Vitamin D + K2 (for cardiovascular and bone health)
– Alpha-lipoic acid (for mitochondrial health)
– CoQ10 (especially important if taking statins)
– Berberine (a natural AMPK activator)

We’ve curated a collection of supplements inspired by Sinclair’s most talked-about ingredients — made for people who want to take healthy ageing seriously.
👉 Explore the full collection

David Sinclair’s approach isn’t about shortcuts or fads. It’s about understanding how ageing works — and giving your body the tools to repair, defend, and perform at its best. If you’re starting your own longevity stack, his routine offers a science-backed roadmap — and For Youth makes it easy to follow through with clean, effective formulations.