Bryan Johnson’s Supplement Stack: Inside the Blueprint for Longevity

Bryan Johnson, founder of Kernel and Blueprint, has become a household name in the world of radical longevity. With a multimillion-dollar health optimisation routine designed to slow and even reverse ageing, Johnson takes more than 100 supplements daily and undergoes extensive testing to monitor every aspect of his biology.

Among his protocol are a few standout ingredients that For Youth also champions — backed by science and aligned with core longevity pathways like sirtuin activation, mitochondrial support, and NAD⁺ replenishment.

NMN is one of the cornerstone ingredients in Bryan Johnson’s protocol. As a precursor to NAD⁺, NMN helps fuel mitochondrial energy production, DNA repair, and sirtuin activation — all of which decline with age. Johnson has publicly stated that he takes NMN daily to maintain his biological performance and energy levels.

The Repair delivers 450 mg of high-purity NMN per capsule, while The Base offers a gentle daily foundation:

Bryan Johnson is known to include resveratrol in his anti-ageing stack. This polyphenol activates sirtuins — the same proteins involved in DNA stability, metabolism, and cellular longevity. Resveratrol is most effective when paired with NMN, as one turns on the longevity genes while the other fuels them via NAD⁺.

The Grape delivers 300 mg of trans-resveratrol — clean, potent, and ready to activate your sirtuins:

Johnson has also explored NR — another NAD⁺ precursor — in his earlier protocols and discussion threads. Like NMN, NR works to increase intracellular NAD⁺, with a particular focus on metabolic and neurological function. Including both compounds offers a broad approach to NAD⁺ support.

The Plus is For Youth’s advanced NR formulation — designed for sustained daily activation of cellular repair pathways:

While not the flashiest part of his stack, Bryan Johnson includes magnesium and L-theanine in his Blueprint protocol — for sleep quality, stress reduction, and nervous system recovery. These ingredients support his goal of achieving deep, restorative sleep and optimised cognitive function.

The Unwind combines magnesium L-threonate and L-theanine to help you rest, recover, and perform better — exactly the way Johnson intends:

Inspired by Bryan Johnson’s Blueprint protocol? We’ve curated a clean, high-efficacy collection of supplements aligned with his top longevity ingredients.

👉 Explore the collection

While the core ingredients above are part of Bryan Johnson’s published protocol, he has publicly mentioned or tracked a broad range of other compounds in podcasts and Blueprint updates. These include:

– Vitamin D3 + K2 : For immune regulation, bone health, and cardiovascular support
– Creatine : For brain energy and muscle function
– Omega-3 (EPA/DHA) : For anti-inflammatory and neuroprotective support
– CoQ10 : For mitochondrial health and cardiovascular energy
– Zinc + Selenium : For immune function and antioxidant defence
– Probiotics + Prebiotics : To support gut health and microbiome balance

Bryan Johnson's protocol is intense — but it’s grounded in tracking, experimentation, and long-term cellular support. Even adopting a few of the most validated compounds can help improve energy, clarity, and resilience.

Bryan Johnson’s approach to ageing is both data-driven and deeply proactive. At For Youth, we share that same philosophy: no gimmicks, no guesswork — just the most studied longevity compounds in clean, bioavailable formulas.

Explore our collection and start your own evidence-backed longevity protocol today.