David Sinclair’s Longevity Supplement Stack: What He Takes & Where to Start

Dr. David Sinclair — the Harvard professor and author of Lifespan — is one of the most widely followed scientists in the field of ageing. His personal supplement routine has sparked global interest, with many looking to build their own longevity stacks inspired by his research into NAD+, epigenetics, and cellular resilience.

If you’ve ever wondered “what supplements does David Sinclair actually take?” — here’s a detailed breakdown of the ingredients he’s publicly discussed, what they do, and where to start if you're building your own evidence-led stack.

Sinclair has called NMN the cornerstone of his routine. As a precursor to NAD+, NMN plays a critical role in supporting DNA repair, mitochondrial function, and overall energy metabolism. Sinclair takes NMN every morning — and it’s the supplement that put longevity on the mainstream map.

Try The Repair for high-purity NMN, or The Base for a streamlined daily dose:

Resveratrol is best known as the “red wine molecule,” but Sinclair uses it not for the wine — but for its potential to activate sirtuins. These proteins are thought to influence ageing by improving cellular stress resistance and metabolism. He’s often said he takes resveratrol alongside NMN and yoghurt.

Try The Grape — For Youth’s resveratrol formulated for optimal absorption:

Quercetin is a plant flavonoid known for its antioxidant effects and potential senolytic activity — meaning it may help the body clear out ageing cells. Sinclair has discussed its potential benefits, particularly in combination with compounds like fisetin or pterostilbene.

The Zombie offers bioavailable quercetin designed for long-term cellular defence:

This molecule has gained traction for its role in autophagy — the body’s natural cellular clean-up mechanism. Sinclair has spoken positively about its potential in supporting long-term cellular health, particularly in the context of caloric restriction mimetics.

The Cleanse supports autophagy with high quality spermidine, supported by quercetin and curcumin:

While not at the top of Sinclair’s core list, glutathione is one of the most important antioxidants produced by the body. It plays a key role in detoxification and mitochondrial support — two themes that overlap with Sinclair’s broader approach to ageing.

The Protect delivers reduced glutathione to help shield your cells from oxidative stress:

David Sinclair has also mentioned other compounds in interviews and podcast appearances:
– Fisetin (a senolytic plant polyphenol, similar to quercetin)
– TMG (to support methylation alongside NMN, but lacks scientific evidence)
– Vitamin D + K2 (for cardiovascular and bone health)
– Alpha-lipoic acid (for mitochondrial health)
– CoQ10 (especially important if taking statins)
– Berberine (a natural AMPK activator)

We’ve curated a collection of supplements inspired by Sinclair’s most talked-about ingredients — made for people who want to take healthy ageing seriously.
👉 Explore the full collection

David Sinclair’s approach isn’t about shortcuts or fads. It’s about understanding how ageing works — and giving your body the tools to repair, defend, and perform at its best. If you’re starting your own longevity stack, his routine offers a science-backed roadmap — and For Youth makes it easy to follow through with clean, effective formulations.